When you’re feeling under the weather, a fever can seem like the last thing you need. The immediate reaction for many is to reach for acetaminophen to bring that temperature down as quickly as possible. But what if I told you that fever, that uncomfortable rise in body temperature, might actually be working in your favor—especially if you’re dealing with cancer? Let’s dive into why fevers can be beneficial and why it might be time to rethink reaching for acetaminophen.

Fever: Your Body’s Natural Defense Mechanism

First, let’s understand what a fever really is. A fever is your body’s natural way of fighting off infections and illness. When you’re sick, your immune system responds by raising your body temperature, creating an environment that's less hospitable for bacteria and viruses. This increase in temperature not only helps to kill off pathogens but also boosts your immune response, activating cells that help fight infections.

For cancer patients, this natural immune boost can be particularly important. Fevers have been shown to have anti-cancer benefits, aiding in the fight against malignant cells. Early research even suggested that fevers could trigger remissions in cancer patients. While inducing fevers isn’t commonly used today, modern therapies like hyperthermia still utilize heat to target and weaken cancer cells. So, if your body mounts a fever, it’s often a sign that your immune system is doing what it’s designed to do: protect you.

Why Avoid Acetaminophen for Fevers?

It’s tempting to want to break a fever quickly—no one enjoys feeling hot, sweaty, and uncomfortable. However, when you take acetaminophen to bring down a fever, you’re not just relieving the symptoms; you’re also interrupting your body’s natural defense mechanism. acetaminophen works by lowering your body temperature, which can impair your immune system’s ability to fight off infection effectively. For cancer patients, this can be particularly problematic, as their immune systems are often already compromised. By suppressing a fever, acetaminophen may inadvertently prolong illness and slow down recovery.

Even more concerning is acetaminophen’s impact on cancer treatments, particularly immunotherapy. Immunotherapy works by enhancing your body’s immune response against cancer, and a fever can be a sign that the treatment is doing its job. acetaminophen is often given preemptively to prevent fever in patients receiving immunotherapy, but suppressing a fever with acetaminophen during immunotherapy could reduce the treatment’s effectiveness, potentially doing more harm than good.

Acetaminophen and Glutathione: A Hidden Connection

Beyond interfering with your immune response, acetaminophen has another hidden downside: it depletes glutathione, a powerful antioxidant that your body relies on for numerous critical functions. Glutathione plays a key role in supporting your immune system, aiding in detoxification, and protecting your cells from damage. It helps the liver process and eliminates toxins, regulates blood sugar, and is essential for overall health.

When you take acetaminophen, it forces the liver to use up glutathione to process the drug, leading to depletion. This not only puts stress on the liver but also diminishes your body’s natural defenses. Low levels of glutathione are associated with aging, increased risk of infections, and heightened vulnerability to liver damage—all issues that cancer patients, in particular, need to avoid.

How to Support Glutathione Levels

Luckily, there are ways to support and boost your glutathione levels naturally. One approach is through your diet. Foods rich in N-acetylcysteine (NAC), a precursor to glutathione, can help replenish your body’s stores. You’ll find NAC in protein-rich foods like meat, yogurt, egg yolks, and cruciferous vegetables such as broccoli, cauliflower, and Brussels sprouts. Garlic and onion are also excellent sources that provide the building blocks needed for glutathione production.

Supplementing with NAC can be another effective way to increase glutathione levels. Other antioxidants like Vitamin C, Vitamin E, quercetin, zinc, selenium, and medicinal mushrooms also help to support and protect glutathione in the body.

Fevers and Cancer: A Historical Perspective

The relationship between fevers and cancer isn’t new. In the late 19th and early 20th centuries, Dr. William Coley, known as the "Father of Immunotherapy," used bacterial toxins to induce fevers in cancer patients, which led to several cases of remission. This treatment, known as Coley’s toxins, was one of the earliest forms of immunotherapy, highlighting the potential benefits of fevers in cancer care.

While today’s cancer treatments have evolved, the principles remain the same: the immune system plays a critical role in fighting cancer. Allowing a fever to run its course could potentially assist in the body’s fight against cancer cells, offering a natural boost to treatment.

When to Treat a Fever—and When to Let It Be

So, when should you be concerned about a fever? Generally, if a fever stays below 105°F, it is considered safe for most people, including cancer patients. However, if your fever climbs above this threshold or if you have other concerning symptoms, it’s important to seek medical attention promptly.

For oncology patients, fevers can be a sign of infection, which can become serious quickly due to a weakened immune system. Always consult with your healthcare provider if you experience a fever during cancer treatment. They can help determine the cause and the best course of action.

The Bottom Line

Fevers are a powerful tool that your body uses to fight illness and may even offer benefits in cancer care. While it might be tempting to reach for acetaminophen at the first sign of a fever, consider the potential downsides—particularly if you’re undergoing cancer treatment. Instead of immediately suppressing the fever, allow your body to use its natural defense mechanisms. If you’re ever unsure about how to manage a fever, especially during cancer treatment, reach out to your healthcare provider for guidance.

At Cincinnati Integrative Oncology and Functional Medicine, we’re here to help you navigate every aspect of your cancer care, from the medications you take to how you manage everyday symptoms like fever. Remember, your body is constantly working to protect you—even when it doesn’t feel like it.

This article is for educational purposes only and is not intended to diagnose, treat, or mitigate disease. It may include non-FDA-approved treatments or alternate indications. Please consult your healthcare professional for formal recommendations in your particular case.

Rethinking Acetaminophen: Why Fever Can Be Beneficial for Cancer Patients