Photodynamic Therapy
At Cincinnati Integrative Oncology and Functional Medicine (CIOFM), we know that fighting cancer requires a multifaceted approach that supports your whole body. That’s why we offer innovative therapies that target cancer at its roots while enhancing your overall well-being. One such therapy is Photodynamic Therapy (PDT)—a non-invasive treatment designed to selectively target abnormal cells using light and a special photosensitizing agent.
While PDT is not FDA-approved for cancer treatment, research suggests it may be a valuable adjunct therapy for patients actively managing cancer. By integrating PDT with personalized care strategies, we aim to empower your body’s natural defenses and improve your quality of life.
What is Photodynamic Therapy?
Photodynamic therapy (PDT) uses the power of light to selectively target and destroy unhealthy cells while leaving healthy tissue unharmed.
It works through a two-step process:
Step 1: Photosensitizing Agent
You’ll take a light-sensitive medication, often methylene blue, which absorbs into cells but lingers longer in abnormal ones. This makes the unhealthy cells more vulnerable to treatment. Methylene blue is widely used in medicine and has a strong safety profile, but because it can pose risks for individuals with G6PD deficiency, we’ll conduct a simple test beforehand to ensure it’s safe for you.
Step 2: Light Activation
Once the photosensitizer has settled into the target cells, you’ll use a medical-grade red light box to activate the medication. The red light triggers a reaction that produces oxygen molecules, which break down the membranes and DNA of the unhealthy cells—while sparing healthy tissue.
Cancer thrives in environments of inflammation, oxidative stress, and poor cellular function.
PDT targets these root causes in several important ways:
Targets Cancer Cells While Protecting Healthy Cells – The photosensitizing agent lingers longer in abnormal cells, enhancing precision.
Supports Your Body’s Healing Systems – PDT helps reduce inflammation, oxidative stress, and immune suppression—all of which play key roles in cancer progression.
Non-Invasive and Well-Tolerated – Unlike traditional treatments, PDT has minimal side effects and can be easily integrated into your care plan.
Convenient Home-Based Treatment – With your own medical-grade red light box, you can continue treatments at home twice daily for consistent, long-term benefits.
Frequently Asked Questions
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Photodynamic therapy (PDT) is a non-invasive treatment that uses a combination of a light-sensitive medication (photosensitizer) and red light to target and destroy unhealthy cells. The medication absorbs into abnormal cells, and when exposed to red light, it produces oxygen molecules that damage and break down the unhealthy cells while leaving healthy tissue unharmed.
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PDT works in two steps:
Photosensitizer Absorption – You’ll take a light-sensitive medication like methylene blue that selectively accumulates in abnormal cells.
Light Activation – After the medication has absorbed into the cells, a medical-grade red light is used to activate it. The light triggers a chemical reaction that produces oxygen molecules, which damage and destroy the targeted cells.
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PDT is not FDA-approved for cancer treatment but is used as an adjunct therapy to support the body’s natural healing processes. It may be beneficial for patients managing:
Skin cancer (including actinic keratosis and Bowen disease)
Barrett’s esophagus
Bile duct cancer
Bladder cancer
Esophageal cancer
Head and neck cancer
Lung cancer
Pancreatic cancer
Pre-cancerous conditions
Inflammation and oxidative stress
Memory and cognitive function (may benefit those with Alzheimer’s)
Depression and anxiety
Joint pain and inflammation
Acne and other skin conditions
Anti-aging benefits like improved skin tone and reduced wrinkles
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Yes, PDT is generally well-tolerated with minimal side effects. However, it’s not suitable for everyone. PDT is contraindicated for individuals who:
Are taking SSRIs (selective serotonin reuptake inhibitors)
Are pregnant
Have a G6PD deficiency (we conduct a simple test beforehand to confirm it's safe for you)
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Methylene blue is effective because it selectively accumulates in abnormal cells, making them more vulnerable to light-based treatment. It also offers additional health benefits, including:
Reducing inflammation that can promote cancer growth
Supporting mitochondrial function to improve cellular energy production
Enhancing cognitive function to combat brain fog and fatigue
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No, PDT at CIOFM is designed for convenient at-home use. Once your provider has confirmed PDT is right for you, you’ll be guided through purchasing a medical-grade red light box for at-home treatments.
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Most patients are advised to use the red light box twice daily for about 15–30 minutes per session. Your provider will create a personalized plan based on your needs.
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PDT is generally well-tolerated. Some patients experience mild redness, swelling, or sensitivity in the treated area, especially if the skin is exposed to bright light or sunlight shortly after treatment. These side effects are usually temporary and resolve within a few days.
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Yes, PDT is often combined with other integrative treatments like:
Ketogenic diets – To create an environment less supportive of cancer cell growth.
Fasting protocols – To increase cancer cell sensitivity to treatment.
Immune support therapies – To strengthen the body’s natural defenses.
Dr. Jamie will work with you to design a treatment plan that integrates PDT with other therapies tailored to your health goals.
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Results vary depending on the condition being treated and the individual response to therapy. Some patients notice improvements in symptoms and energy levels within a few weeks, while others may require ongoing treatment to achieve the best results.
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Since PDT for cancer treatment is not FDA-approved, it is typically not covered by insurance.
Interested in Photodynamic Therapy?
If you’re a CIOFM member, contact your provider through the patient portal to discuss whether Photodynamic Therapy is a good fit for your treatment plan.
If you’re interested in exploring treatment with Dr. Jamie and the CIOFM team, read our New Patient Information to learn more about how to schedule an initial consultation and become a member of our practice.
When you’re ready, schedule a Discovery Call to take the first step toward personalized, integrative cancer care!